Temazepam may possibly lower the excretion rate of Acetaminophen which could result in a greater serum stage.Observe Closely (one)crofelemer boosts levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Crofelemer has the potential to inhibit CYP3A4 at concentrations anticipated within the gut; not likely